Curso académico 2018/19

Actividades realizadas

 

 

  • Buscador de estudios con animales en la UMH: http://research.umh.es/vivo/
    • Instrucciones de uso:
      • En el cajón buscador introducir la especie animal y el año. Ejemplo: Mice 2018
      • En el menú que aparece a la derecha seleccionar: Research
      • Aparecerán los artículos y posters relacionados
      • También se puede acotar la búsqueda por enfermedades. Ejemplo: Anxiety mice 2018
  • Actividades de divulgación:
    • Jornada de puertas abiertas en la Semana Mundial del Cerebro celebrada los días 11-17 de Marzo de 2019 en el Instituto de Neurociencias, centro mixto UMH-CSIC, donde se abordó el tema con diferentes charlas divulgativas, exposiciones…
    • I Jornada de puertas abiertas de la Facultad de Medicina de la UMH celebrada el día 3 de Octubre de 2018, en la que se impartió el Taller «Aprendiendo de los animales» a alumnos de primaria y secundaria, donde se explicó la importancia y la necesidad que sigue habiendo hoy en día del uso de animales en la investigación.
    • Vídeo divulgativo sobre el Servicio de Experimentación Animal de la UMH:
    • Visitas guiadas a los animalarios para alumnos de:
      • Centros de educación secundaria
      • Estudiantes de grado

Uso de animales en experimentación en la UMH en el año 2018

El número de animales utilizados por primera vez (en su primer uso) con fines de investigación y ensayo, para docencia, así como para la creación y el mantenimiento de líneas animales genéticamente alteradas en la UMH ha sido superior a los 10.000 animales en el año 2018. Sin embargo, se observa una ligera tendencia a la baja en comparación con el año 2017 (n = 13176 usos).

El año 2018, los animales usados en la Universidad Miguel Hernández representaron un 1,44% del total usado en España en 2018 (n = 836.096). Los mamíferos han constituido un 94,3% (n = 11402) de los animales usados en experimentación, siendo las especies utilizadas: el ratón, la rata, el hurón, la cobaya, el conejo y el cerdo. Los peces han constituido el 5,7% (n = 684) de los animales restantes.

número animales UMH 2018

El siguiente gráfico representa la proporción de animales que ha sido sometida a un procedimiento con un determinado grado de severidad. Se observa que el grado de severidad de los procedimientos que predomina es «Sin recuperación» con 4242 animales (35,1%), seguido de la severidad «Moderada» (n = 3075, 30,65%), severidad «Leve» (n = 2598, 21,5%) y, por último, «Severa» con 1541 animales (12,75%). En el informe de 2018 del Ministerio de Agricultura, Pesca y Alimentación, el porcentaje de procedimientos «Sin recuperación» y «Leve (como máximo)» se desvían considerablemente de los de la UMH («Sin recuperación» 4,75%, y «Leve (como máximo)» 52,12%); mientras que el porcentaje de procedimientos con severidad «Moderada» y «Severa» es similar: 35,90% y 7,22%, respectivamente.

En cuanto a la información recogida respecto a la finalidad científica del uso de los animales, destaca el uso de la investigación básica (81%) predominando la investigación en el «Sistema nervioso». La investigación traslacional y aplicada este año solamente ha representado el 7,2% de los usos, siendo la «Enfermedad de los animales» el principal campo de investigación.

Se puede encontrar más información en el informe de transparencia que se encuentra al principio de esta página.

Información relativa al uso de animales de experimentación en España:

Información relativa al uso de animales de experimentación en Europa:

Artículos publicados

  1. The centrosome protein AKNA regulates neurogenesis via microtubule organization
  2. Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models
  3. Rag1 immunodeficiency-induced early aging and senescence in zebrafish are dependent on chronic inflammation and oxidative stress
  4. Regulatory T Cells Restrict Permeability to Bacterial Antigen Translocation and Preserve Short-Chain Fatty Acids in Experimental Cirrhosis
  5. Prenatal activity from thalamic neurons governs the emergence of functional cortical maps in mice
  6. Timing of Exposure and Bisphenol-A: Implications for Diabetes Development
  7. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis
  8. FXR modulates the gut-vascular barrier by regulating the entry sites for bacterial translocation in experimental cirrhosis
  9. Effects of corneal injury on ciliary nerve fibre activity and corneal nociception in mice: A behavioural and electrophysiological study
  10. CBP and SRF co-regulate dendritic growth and synaptic maturation
  11. Effect of stress on somatic cell count and milk yield and composition in goats
  12. The Immunosuppressant Macrolide Tacrolimus Activates Cold-Sensing TRPM8 Channels
  13. Cannabidiol regulates the expression of hypothalamus-pituitary-adrenal axis-related genes in response to acute restraint stress
  14. Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits
  15. A Retino-retinal Projection Guided by Unc5c Emerged in Species with Retinal Waves
  16. O-hexyl O-2,5-dichlorophenyl phosphoramidate as a substrate for domestic and sea bird serum A-esterases: Hydrolysis levels, Cu(2+)- and Zn(2+)-dependence and stereoselectivity
  17. Pancreatic alpha-cell mass in the early-onset and advanced stage of a mouse model of experimental autoimmune diabetes
  18. Impact of Different Titanium Implant Thread Designs on Bone Healing: A Biomechanical and Histometric Study with an Animal Model
  19. Cannabidiol does not display drug abuse potential in mice behavior
  20. Distribution of GABAergic Neurons and VGluT1 and VGAT Immunoreactive Boutons in the Ferret (Mustela putorius) Piriform Cortex and Endopiriform Nucleus. Comparison With Visual Areas 17, 18 and 19
  21. Extensive branching of radially-migrating neurons in the mammalian cerebral cortex
  22. Rainbow Trout Red Blood Cells Exposed to Viral Hemorrhagic Septicemia Virus Up-Regulate Antigen-Processing Mechanisms and MHC I&II, CD86, and CD83 Antigen-presenting Cell Markers
  23. Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis
  24. The Amniote Oculomotor Complex
  25. CBP/p300 in brain development and plasticity: disentangling the KAT’s cradle
  26. Biomechanical and Histological Analysis of Titanium (Machined and Treated Surface) Versus Zirconia Implant Materials: An In Vivo Animal Study
  27. Decreased circulating ErbB4 ectodomain fragments as a read-out of impaired signaling function in amyotrophic lateral sclerosis
  28. Plasma proteomic analysis of zebrafish following spring viremia of carp virus infection
  29. Microstructural White Matter Alterations in Men With Alcohol Use Disorder and Rats With Excessive Alcohol Consumption During Early Abstinence
  30. The calmodulin-binding tetraleucine motif of KCNE4 is responsible for association with Kv1.3
  31. IFIT5 Participates in the Antiviral Mechanisms of Rainbow Trout Red Blood Cells
  32. Expression of the cold thermoreceptor TRPM8 in rodent brain thermoregulatory circuits
  33. The peripheral eye: A neurogenic area with potential to treat retinal pathologies?
  34. Determination of intestinal permeability using in situ perfusion model in rats: Challenges and advantages to BCS classification applied to digoxin
  35. In utero exposure to bisphenol-A disrupts key elements of retinoid system in male mice offspring
  36. The Epigenetic Factor CBP Is Required for the Differentiation and Function of Medial Ganglionic Eminence-Derived Interneurons
  37. Location and Plasticity of the Sodium Spike Initiation Zone in Nociceptive Terminals In Vivo
  38. Loss of Cntnap2 Causes Axonal Excitability Deficits, Developmental Delay in Cortical Myelination, and Abnormal Stereotyped Motor Behavior
  39. A 3D Convolutional Neural Network to Model Retinal Ganglion Cell’s Responses to Light Patterns in Mice
  40. 1-(2′,5′-Dihydroxyphenyl)-3-(2-fluoro-4-hydroxyphenyl)-1-propanone (RGM079): A Positive Allosteric Modulator of a7 Nicotinic Receptors with Analgesic and Neuroprotective Activity
  41. Improved hemodynamic and liver function in portal hypertensive cirrhotic rats after administration of B. pseudocatenulatum CECT 7765
  42. TherMouseDuino: An affordable Open-Source temperature control system for functional magnetic resonance imaging experimentation with mice
  43. Non-invasive MRI windows to neuroinflammation
  44. Fish Red Blood Cells Modulate Immune Genes in Response to Bacterial Inclusion Bodies Made of TNFa and a G-VHSV Fragment
  45. The occurrence and dynamics of polychlorinated hydrocarbons in roe deer (Capreolus capreolus) in South-western Slovakia
  46. Emerging evidence for the modulation of exocytosis by signalling lipids
  47. Turbot (Scophthalmus maximus) Nk-lysin induces protection against the pathogenic parasite Philasterides dicentrarchi via membrane disruption
  48. Correlated response in body condition and energy mobilisation in rabbits selected for litter size variability
  49. Transcranial direct-current stimulation (tDCS) improves detection of simple bright stimuli by amblyopic Long Evans rats in the SLAG task and produces an increase of parvoalbumin labelled cells in visual cortices
  50. Hydroxycholesterol binds and enhances the anti-viral activities of zebrafish monomeric c-reactive protein isoforms
  51. Potential Role of Rainbow Trout Erythrocytes as Mediators in the Immune Response Induced by a DNA Vaccine in Fish
  52. Microgrooves and Microrugosities in Titanium Implant Surfaces: An In Vitro and In Vivo Evaluation
  53. Litter Survival Differences between Divergently Selected Lines for Environmental Sensitivity in Rabbits
  54. Rainbow Trout Erythrocytes ex vivo Transfection With a DNA Vaccine Encoding VHSV Glycoprotein G Induces an Antiviral Immune Response
  55. Double Drug Delivery Using Capped Mesoporous Silica Microparticles for the Effective Treatment of Inflammatory Bowel Disease
  56. Integrated Transcriptomic and Proteomic Analysis of Red Blood Cells from Rainbow Trout Challenged with VHSV Point Towards Novel Immunomodulant Targets
  57. Chromatin immunoprecipitation and high throughput sequencing of SVCV-infected zebrafish reveals novel epigenetic histone methylation patterns involved in antiviral immune response
  58. Using Drosophila Models and Tools to Understand the Mechanisms of Novel Human Cancer Driver Gene Function
  59. Correlated response to selection for litter size environmental variability in rabbits’ resilience
  60. The caudo-ventral pallium is a novel pallial domain expressing Gdf10 and generating Ebf3-positive neurons of the medial amygdala
  61. Pharmacological regulation of cannabinoid CB2 receptor modulates the reinforcing and motivational actions of ethanol
  62. Influence of hydroxyapatite granule size, porosity, and crystallinity on tissue reaction in vivo. Part B: a comparative study with biphasic synthetic biomaterials
  63. Gender differences in the effects of cannabidiol on ethanol binge drinking in mice
  64. Demineralized Bone Matrix Coating Si-Ca-P Ceramic Does Not Improve the Osseointegration of the Scaffold
  65. Copper-dependent hydrolysis of trichloronate by turkey serum studied with use of new analytical procedure based on application of chiral chromatography and UV/Vis spectrophotometry
  66. The Megalocytivirus RBIV Induces Apoptosis and MHC Class I Presentation in Rock Bream (Oplegnathus fasciatus) Red Blood Cells
  67. Synaptic mechanisms underlying the intense firing of neocortical layer 5B pyramidal neurons in response to cortico-cortical inputs
  68. Gene delivery to the rat retina by non-viral vectors based on chloroquine-containing cationic niosomes
  69. Bisphenol A Regulates Sodium Ramp Currents in Mouse Dorsal Root Ganglion Neurons and Increases Nociception
  70. Cortistatin regulates glucose-induced electrical activity and insulin secretion in mouse pancreatic beta-cells
  71. Deletion of Dlk1 increases the vulnerability to developing anxiety-like behaviors and ethanol consumption in mice
  72. A Chronic Ocular-Hypertensive Rat Model induced by Injection of the Sclerosant Agent Polidocanol in the Aqueous Humor Outflow Pathway
  73. Selective neuronal death following exposure to methylenedioxypyrovalerone is accompanied by an inhibition of NMDA receptor NR2B subunit expression
  74. Influence of Olive Extracts on the Expression of Genes Involved in Lipid Metabolism in Medaka Fish
  75. Gene transfer to rat cerebral cortex mediated by polysorbate 80 and poloxamer 188 nonionic surfactant vesicles
  76. Single versus double experimental bile duct ligation model for inducing bacterial translocation
  77. Non-viral vectors based on cationic niosomes as efficient gene delivery vehicles to central nervous system cells into the brain
  78. Polysorbate 20 non-ionic surfactant enhances retinal gene delivery efficiency of cationic niosomes after intravitreal and subretinal administration
  79. Complex hybridization patterns in European pond turtles (Emys orbicularis) in the Pyrenean Region
  80. Non-viral vectors based on cationic niosomes and minicircle DNA technology enhance gene delivery efficiency for biomedical applications in retinal disorders
  81. Different behavior of polyphenols in energy metabolism of lipopolysaccharide-stimulated cells
  82. Impact on intestinal permeability of pediatric hyperosmolar formulations after dilution: Studies with rat perfusion method
  83. Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs
  84. Multiscale dynamics of interstimulus interval integration in visual cortex
  85. Comparative study of extracellular recording methods for analysis of afferent sensory information: Empirical modeling, data analysis and interpretation
  86. Ion-pair approach coupled with nanoparticle formation to increase bioavailability of a low permeability charged drug