Año 2020

Actividades realizadas

  • Programas R de Responsable:

Primer programa: Del animalario a las residencias de ancianos, la crisis de la COVID-19

 

  • Publicación de una Guía de búsqueda de métodos alternativos en investigación animal.
    • Estrategia de búsqueda piramidal
      • Fase 1: Búsqueda en bases de datos de valor añadido (específicas de métodos alternativos)
      • Fase 2: Búsqueda en bases de datos de cobertura amplia limitada por nosotros
      • Fase 3: Búsqueda en bases de datos de cobertura amplia y muy amplia sin limitar
    • Tutorial
  • Desarrollo de una Guía para el cálculo del tamaño muestral.
    • Explicación de los conceptos elementales:
      • Efecto o diferencia
      • Variabilidad
      • Potencia o probabilidad de error de tipo II
      • Nivel de significación o probabilidad de error de tipo I
    • Introducción a GPower
      • Ejemplo para el cálculo muestral en el supuesto de comparación de medias
      • Ejemplo para el cálculo muestral en el supuesto de comparación de proporciones

Artículos publicados

  1. Low-dimensional dynamics for working memory and time encoding
  2. Piezo2 Mediates Low-Threshold Mechanically Evoked Pain in the Cornea
  3. Tau phosphorylation by glycogen synthase kinase 3ß modulates enzyme acetylcholinesterase expression
  4. Cannabidiol Modulates Behavioural and Gene Expression Alterations Induced by Spontaneous Cocaine Withdrawal
  5. Adaptive short-term associative conditioning in the pancreatic ß-cell
  6. Highly functionalized ß-lactams and 2-ketopiperazines as TRPM8 antagonists with antiallodynic activity
  7. Programming effects of peripubertal stress on spatial learning
  8. Neuronal tangential migration from Nkx2.1-positive hypothalamus
  9. Effects of the technique and drill design used during the osteotomy on the thermal and histological stimulation
  10. The effect of different sample collection methods on rabbit blood parameters
  11. Protective role of neuronal and lymphoid cannabinoid CB(2) receptors in neuropathic pain
  12. Topical treatment with a mu opioid receptor agonist alleviates corneal allodynia and corneal nerve sensitization in mice
  13. Liver Sinusoidal Endothelial Cells Contribute to Hepatic Antigen-Presenting Cell Function and Th17 Expansion in Cirrhosis
  14. Combined intramuscular and intraspinal transplant of bone marrow cells improves neuromuscular function in the SOD1(G93A) mice
  15. Identification of functional mutations associated with environmental variance of litter size in rabbits
  16. Surfactant-Triggered Molecular Gate Tested on Different Mesoporous Silica Supports for Gastrointestinal Controlled Delivery
  17. Functional Heterogeneity of Mouse and Human Brain OPCs: Relevance for Preclinical Studies in Multiple Sclerosis
  18. Surgical Induction of Endometriosis in Female Mice
  19. Repression of Irs2 by let-7 miRNAs is essential for homeostasis of the telencephalic neuroepithelium
  20. Correlated Response to Selection for Litter Size Residual Variability in Rabbits’ Body Condition
  21. Long-Term Feeding of Dairy Goats with Broccoli By-Product and Artichoke Plant Silages: Milk Yield, Quality and Composition
  22. Short-Term Effect of the Inclusion of Silage Artichoke By-Products in Diets of Dairy Goats on Milk Quality
  23. Can changes in implant macrogeometry accelerate the osseointegration process?: An in vivo experimental biomechanical and histological evaluations
  24. Dysbiosis in marine aquaculture revealed through microbiome analysis: reverse ecology for environmental sustainability
  25. Layer 2/3 Pyramidal Neurons of the Mouse Granular Retrosplenial Cortex and Their Innervation by Cortico-Cortical Axons
  26. Early Stimulation of TREK Channel Transcription and Activity Induced by Oxaliplatin-Dependent Cytosolic Acidification
  27. The beneficial effect of clove essential oil and its major component, eugenol, on erectile function in diabetic rats
  28. Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasks
  29. Composition, Mineral and Fatty Acid Profiles of Milk from Goats Fed with Different Proportions of Broccoli and Artichoke Plant By-Products
  30. KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain
  31. Transient Hypothyroidism During Lactation Alters the Development of the Corpus Callosum in Rats. An in vivo Magnetic Resonance Image and Electron Microscopy Study
  32. Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions
  33. The Beneficial Effects of Lippia Citriodora Extract on Diet-Induced Obesity in Mice Are Associated with Modulation in the Gut Microbiota Composition
  34. Bisphenol-A exposure during pregnancy alters pancreatic ß-cell division and mass in male mice offspring: A role for ERß
  35. A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA(1)), UCM-05194, Shows Efficacy in Neuropathic Pain Amelioration
  36. Inflammatory Correlated Response in Two Lines of Rabbit Selected Divergently for Litter Size Environmental Variability
  37. Freezing Displayed by Others Is a Learned Cue of Danger Resulting from Co-experiencing Own Freezing and Shock
  38. USH2A is a Meissner’s corpuscle protein necessary for normal vibration sensing in mice and humans
  39. Chronic alcohol consumption alters extracellular space geometry and transmitter diffusion in the brain
  40. The prebiotic properties of Hibiscus sabdariffa extract contribute to the beneficial effects in diet-induced obesity in mice
  41. Shape perception via a high-channel-count neuroprosthesis in monkey visual cortex
  42. Zebrafish C-reactive protein isoforms inhibit SVCV replication by blocking autophagy through interactions with cell membrane cholesterol
  43. Transcriptomic Analysis Reveals the Wound Healing Activity of Mussel Myticin C
  44. Effect of Common Excipients on Intestinal Drug Absorption in Wistar Rats
  45. Segmental-Dependent Solubility and Permeability as Key Factors Guiding Controlled Release Drug Product Development
  46. SGK1.1 Reduces Kainic Acid-Induced Seizure Severity and Leads to Rapid Termination of Seizures
  47. Effect of thickener on disintegration, dissolution and permeability of common drug products for elderly patients
  48. Brain Angiogenesis Induced by Nonviral Gene Therapy with Potential Therapeutic Benefits for Central Nervous System Diseases
  49. Netrin-1/DCC Signaling Differentially Regulates the Migration of Pax7, Nkx6.1, Irx2, Otp, and Otx2 Cell Populations in the Developing Interpeduncular Nucleus